Terlipressin-induced ventricular arrhythmia
Ján Urge1, Frantisek Sincl, Vlastimil Procházka
1Department of Internal Medicine II, Faculty of Medicine and Dentistry, Palacky University, University Hospital, Olomouc, Czech Republic.
Abstract:
During intravenous treatment with terlipressin for recurrent gastrointestinal (GI) bleeding, a 50-year-old male with no history of heart disease developed a newly prolonged QT interval and torsade de pointes. Risk factors present for acquired long QT syndrome were mineral dysbalance and a history of alcohol abuse with hepatic impairment. The patient was brought back to a normal sinus rhythm after a single 300-J counter-shock. Terlipressin was discontinued, and the patient's QTc interval subsequently returned to baseline. During 6 weeks of monitoring, arrhythmia did not recur.
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