Related Experiment Video

Updated: Jul 3, 2026

Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice
06:35

Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice

Published on: June 28, 2021

Plasma ADAMTS13 activity parallels the APACHE II score, reflecting an early prognostic indicator for patients with

Chie Morioka1, Masahito Uemura, Tomomi Matsuyama

  • 1Third Department of Internal Medicine, Nara Medical University, Kashihara, Nara, Japan.

Scandinavian Journal of Gastroenterology
|July 9, 2008
PubMed
Abstract

Insights

Severe acute pancreatitis (SAP) involves decreased ADAMTS13 activity, leading to multiorgan failure. Lower ADAMTS13 activity strongly correlates with higher APACHE II scores, indicating its potential as an early prognostic indicator for SAP.

Area of Science:

  • Gastroenterology and Hepatology
  • Hematology
  • Critical Care Medicine

Background:

  • Severe acute pancreatitis (SAP) is a critical condition often leading to multiorgan failure (MOF) and high mortality.
  • Reduced plasma ADAMTS13 activity (ADAMTS13:AC) contributes to MOF by causing accumulation of large von Willebrand factor multimers (UL-VWFM) and platelet thrombi.

Purpose of the Study:

  • To investigate the role of ADAMTS13:AC in the severity of SAP.
  • To determine if ADAMTS13:AC can serve as an early prognostic indicator for SAP patients.

Main Methods:

  • Sequential measurement of plasma ADAMTS13:AC and related parameters in 13 SAP patients using chromogenic act-ELISA.
  • Assessment of von Willebrand factor antigen (VWF:Ag), interleukin 6 (IL-6), and interleukin 8 (IL-8) levels.
  • Correlation analysis with clinical severity scores like APACHE II and SOFA.

Main Results:

  • ADAMTS13:AC was significantly lower in SAP patients (28%) compared to healthy controls (99%) upon admission.
  • Lower ADAMTS13:AC correlated inversely with APACHE II scores (r=-0.750, p<0.005) and higher SOFA scores.
  • Elevated VWF:Ag and inflammatory markers (IL-6, IL-8) were observed in SAP patients, particularly those with UL-VWFM and poorer outcomes.
  • ADAMTS13:AC gradually recovered in survivors but decreased further in non-survivors.

Conclusions:

  • Plasma ADAMTS13:AC is closely related to the APACHE II score in SAP patients.
  • ADAMTS13:AC may function as an early prognostic biomarker for SAP severity.
  • The imbalance between reduced ADAMTS13:AC and increased UL-VWFM may drive SAP pathogenesis via enhanced thrombogenesis.

More Related Videos

Preparing a Mice Model of Severe Acute Pancreatitis via a Combination of Caerulein and Lipopolysaccharide Intraperitoneal Injection07:38

Preparing a Mice Model of Severe Acute Pancreatitis via a Combination of Caerulein and Lipopolysaccharide Intraperitoneal Injection

Published on: May 10, 2024

Navigating the Mass Spectrometry-Based Proteomic Data Using Free Computational Tools07:01

Navigating the Mass Spectrometry-Based Proteomic Data Using Free Computational Tools

Published on: August 19, 2025

Related Concept Videos

Acute Pancreatitis II: Clinical Manifestations and Management01:30

Acute Pancreatitis II: Clinical Manifestations and Management

Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
Acute Pancreatitis II: Pathophysiology01:21

Acute Pancreatitis II: Pathophysiology

The pathophysiology of acute pancreatitis centers on injury to pancreatic acinar cells, which initiates a cascade of harmful intracellular events.This injury leads to premature activation of trypsinogen to trypsin in the pancreas. Trypsin then activates other digestive enzymes, such as chymotrypsin, elastase, and phospholipase A2, which begin breaking down pancreatic tissue. The resulting autodigestion causes local inflammation, tissue swelling, hemorrhage, and fat necrosis.Injured acinar cells...
Acute Pancreatitis I: Introduction01:25

Acute Pancreatitis I: Introduction

Acute pancreatitis is the sudden inflammation of the pancreas caused by the early activation of digestive enzymes, leading to the autodigestion of pancreatic tissue. This results in local inflammation and, in severe cases, systemic complications.EtiologyUnderstanding the underlying causes is crucial, as identifying the etiology guides treatment and anticipates complications. Acute pancreatitis can be triggered by various factors, typically grouped into the following clinical categories.Biliary...
Acute Pancreatitis I: Introduction01:27

Acute Pancreatitis I: Introduction

Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include: