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Related Concept Videos

Protein Organization01:24

Protein Organization

Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
The primary structure of a protein is its amino acid sequence.
Protein Organization01:13

Protein Organization

Overview
Antibody Structure01:10

Antibody Structure

Overview
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
Antibody Structure01:10

Antibody Structure

Overview
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
Protein Folding01:22

Protein Folding

Overview
Protein Folding01:25

Protein Folding

Proteins are chains of amino acids linked together by peptide bonds. Upon synthesis, a protein folds into a three-dimensional conformation, critical to its biological function. Interactions between its constituent amino acids guide protein folding, and hence the protein structure is primarily dependent on its amino acid sequence.
Protein Structure Is Critical to Its Biological Function
Proteins perform a wide range of biological functions such as catalyzing chemical reactions, providing...

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Related Experiment Video

Updated: Jul 3, 2026

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web
09:51

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web

Published on: July 16, 2017

[Novel structural tree for beta-proteins containing abcd-units].

A B Gordeev, M S Kondratova, A V Efimov

    Molekuliarnaia Biologiia
    |July 10, 2008
    PubMed
    Summary
    This summary is machine-generated.

    A comprehensive database and novel structural tree of beta-proteins with abcd-units were created. This resource classifies 153 unique polypeptide chain folds for beta-protein structures.

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    Last Updated: Jul 3, 2026

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    Application of I TASSER, trRosetta, UCSF Chimera, HADDOCK server, and HEX loria for De Novo and In Silico Design of Proteins

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    Area of Science:

    • Structural biology
    • Bioinformatics
    • Protein science

    Context:

    • The Protein Data Bank (PDB) contains numerous protein entries.
    • Beta-proteins and beta-domains with abcd-units represent a significant structural class.
    • A systematic classification is needed for these proteins.

    Purpose:

    • To compile a comprehensive database of beta-proteins and beta-domains containing abcd-units.
    • To construct a novel structural tree for this protein class.
    • To develop a structural classification system based on the tree.

    Summary:

    • A database of 528 beta-proteins and beta-domains with abcd-units was compiled from 1511 PDB entries, including 244 nonhomologous entries.
    • A novel structural tree encompassing 153 possible polypeptide chain folds was constructed for this protein structural class.
    • A structural classification of beta-proteins containing abcd-units was developed, utilizing the constructed tree.

    Impact:

    • Provides a valuable resource for researchers studying beta-protein structures.
    • Facilitates deeper understanding of protein structural diversity and evolution.
    • Enables more accurate protein structure prediction and analysis.