Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...

Venous Thrombosis III: Interprofessional Care

Venous Thrombosis III: Interprofessional Care

Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...

Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants

Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants

Oral anticoagulants are vital tools in preventing and treating blood clotting disorders. This diverse class of medications can be categorized as vitamin K antagonists, exemplified by warfarin, and direct thrombin inhibitors (DTIs), such as dabigatran, as well as factor Xa inhibitors, including rivaroxaban.
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...

Determination of Multiple Dosing Parameters: Steady-State, Minimum and Maximum Concentrations

Determination of Multiple Dosing Parameters: Steady-State, Minimum and Maximum Concentrations

Gentamicin, an aminoglycoside antibiotic, is commonly administered via intermittent intravenous infusion to treat severe infections. An intermittent one-hour infusion of gentamicin, administered at eight-hour intervals, allows for precise control of plasma drug concentrations, minimizing toxicity while ensuring therapeutic efficacy. Pharmacokinetic principles govern the dynamics of plasma concentrations and can be mathematically described using specific equations.The plasma drug concentration...

Hemodialysis II: Procedure and Complications

Hemodialysis II: Procedure and Complications

DialyzersA hemodialysis (HD) dialyzer is a plastic cartridge containing thousands of parallel hollow fibers, which serve as semipermeable membranes. These fibers are typically made from cellulose-based or other synthetic materials. During HD, blood is pumped into the top of the cartridge and distributed among these fibers. Simultaneously, dialysis fluid, known as dialysate, is introduced into the bottom of the cartridge, bathing the outside of the fibers. Across the semipermeable membrane,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Echocardiographer-Led Combined Transjugular Intracardiac Echocardiography and Transesophageal Echocardiography for Tricuspid Transcatheter Edge-to-Edge Repair.

JACC. Case reports·2026

Same author

Management and Outcome of Failed Transcatheter Tricuspid Edge-to-Edge Repair: Insights From the FATE International Registry.

JACC. Cardiovascular interventions·2026

Same author

The ALT FLOW early feasibility study 3-year results assessing left atrial to coronary sinus shunting in HFpEF.

ESC heart failure·2026

Same author

Frailty in patients undergoing percutaneous left atrial appendage closure: The Frail-LAAC study.

Heart rhythm·2026

Same author

Opening Up the Future of Valvular Heart Disease.

The Canadian journal of cardiology·2025

Same author

Short-Term Anticoagulation Versus Dual Antiplatelet Therapy for Preventing Device Thrombosis Following Left Atrial Appendage Closure: The ANDES Randomized Clinical Trial.

Circulation·2025

Search research articles

Related Experiment Video

Updated: Jul 3, 2026

Polyelectrolyte Complex for Heparin Binding Domain Osteogenic Growth Factor Delivery

Polyelectrolyte Complex for Heparin Binding Domain Osteogenic Growth Factor Delivery

Published on: August 22, 2016

Which heparin and how much?

Peter E Ruchin¹, Marino Labinaz

¹Cardiac Catheterization Laboratory, University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, Ontario, Canada K1Y 4W7.

Current Cardiology Reports

|July 10, 2008

Summary

Low molecular weight heparin (LMWH) shows improved outcomes in noninvasive acute coronary syndrome (ACS) treatment but faces challenges in invasive ACS management due to bleeding risks and complex reversal. Further research is needed for optimal antithrombotic therapy selection.

Area of Science:

Cardiology
Pharmacology

Background:

Acute coronary syndromes (ACS) are common emergency department presentations.
Optimizing antithrombotic therapy is crucial for managing ACS, balancing efficacy and safety.
Low molecular weight heparin (LMWH) offers benefits over unfractionated heparin in some ACS cases.

Purpose of the Study:

To evaluate the risk-benefit ratio of antithrombotic therapy in ACS.
To compare the efficacy and safety of LMWH versus other agents in ACS management.
To address concerns regarding LMWH use in specific patient populations and procedural contexts.

Main Methods:

Review of existing literature on antithrombotic therapies in ACS.
Analysis of clinical outcomes, including cardiovascular events and bleeding risks.

More Related Videos

Through-the-Wall Blood Sampling Method to Minimize Sleep Disruption in Clinical Settings

Through-the-Wall Blood Sampling Method to Minimize Sleep Disruption in Clinical Settings

Published on: June 13, 2025

Rapid Point-of-Care Assay of Enoxaparin Anticoagulant Efficacy in Whole Blood

Rapid Point-of-Care Assay of Enoxaparin Anticoagulant Efficacy in Whole Blood

Published on: October 12, 2012

Related Experiment Videos

Last Updated: Jul 3, 2026

Polyelectrolyte Complex for Heparin Binding Domain Osteogenic Growth Factor Delivery

Polyelectrolyte Complex for Heparin Binding Domain Osteogenic Growth Factor Delivery

Published on: August 22, 2016

Through-the-Wall Blood Sampling Method to Minimize Sleep Disruption in Clinical Settings

Through-the-Wall Blood Sampling Method to Minimize Sleep Disruption in Clinical Settings

Published on: June 13, 2025

Rapid Point-of-Care Assay of Enoxaparin Anticoagulant Efficacy in Whole Blood

Rapid Point-of-Care Assay of Enoxaparin Anticoagulant Efficacy in Whole Blood

Published on: October 12, 2012

Assessment of LMWH's pharmacokinetic and pharmacodynamic properties in ACS.

Main Results:

LMWH improves outcomes in noninvasively treated ACS patients compared to unfractionated heparin.
LMWH's superiority in invasively managed ACS is not consistently demonstrated.
Increased bleeding risk with LMWH is noted, particularly in elderly and renally impaired patients.

Conclusions:

The choice of antithrombotic therapy in ACS requires careful consideration of patient factors and treatment strategy.
Concerns about LMWH's bleeding risk, complex reversal, and potential thrombotic events in the cath lab warrant further investigation.
Evidence suggests a nuanced approach to LMWH use in ACS, with ongoing debate regarding its optimal role.