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Measuring Motor Coordination in Mice
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Measuring Motor Coordination in Mice

Published on: May 29, 2013

Early deficits in motor coordination and cognitive dysfunction in a mouse model of the neurodegenerative lysosomal

Maria Gulinello1, Fengying Chen, Kostantin Dobrenis

  • 1Behavioral Core Facility, Dominick S. Purpura Department of Neuroscience, Albert Einstein College of Medicine of Yeshiva University, Bronx, NY, USA.

Behavioural Brain Research
|July 10, 2008
PubMed

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Lysosomal Hydrolases01:22

Lysosomal Hydrolases

Lysosomes are the site for the degradation of macromolecules and biological polymers released during membrane trafficking events such as secretory, endocytic, autophagic, and phagocytic pathways. The membrane-enclosed area of the lysosome, called the lumen, contains hydrolytic enzymes active in an acidic environment. These acid hydrolases are functional at a pH between 4.5 and 5 and are involved in cellular processes such as cell signaling, energy metabolism, restoration of the plasma membrane,...