Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Quinolone pharmacokinetics.

R A Robson1

  • 1Department of Nephrology, Christchurch Hospital, Christchurch, New Zealand.

International Journal of Antimicrobial Agents
|December 1, 1992
PubMed
Summary
This summary is machine-generated.

This review compares fluoroquinolone antibiotics, detailing their pharmacokinetics, including absorption, distribution, metabolism, and elimination. Understanding these factors is crucial for selecting the best fluoroquinolone antibiotic for individual patients.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A combination study design to examine mycophenolate mofetil (MMF) and PTLD in renal transplant patients.

Pharmacoepidemiology and drug safety·2004
Same author

Cost-benefit analysis and prediction of 24-hour proteinuria from the spot urine protein-creatinine ratio.

Clinical nephrology·2001
Same author

Quinapril and its metabolite quinaprilat in human milk.

British journal of clinical pharmacology·2001
Same author

Dimethylglycine accumulates in uremia and predicts elevated plasma homocysteine concentrations.

Kidney international·2001
Same author

Glycine betaine excretion is not directly linked to plasma glucose concentrations in hyperglycaemia.

Diabetes research and clinical practice·2001
Same author

The pharmacokinetics of oral fleroxacin and ciprofloxacin in plasma and sputum during acute and chronic dosing.

British journal of clinical pharmacology·1999
Same journal

Strain-dependent variability in pharmacodynamic interactions for phage-antibiotic combinations in Pseudomonas aeruginosa.

International journal of antimicrobial agents·2026
Same journal

Carbapenem-resistant Enterobacterales across the UK: a nationwide study of carbapenemase testing and novel antimicrobial activity.

International journal of antimicrobial agents·2026
Same journal

Kidney Injury, Dialysis, and Mortality with Vancomycin Plus Piperacillin-Tazobactam or Cefepime.

International journal of antimicrobial agents·2026
Same journal

Ceftaroline pharmacokinetics on ECMO, a pediatric case report.

International journal of antimicrobial agents·2026
Same journal

Cefiderocol Susceptibility Rates in Carbapenem-Resistant Gram-Negative Bacteria in a Comparative, Multicenter Surveillance Study in China.

International journal of antimicrobial agents·2026
Same journal

Antibiotic consumption in Europe, 2019-2024: being AWaRe is not about using less.

International journal of antimicrobial agents·2026
See all related articles

Area of Science:

  • Pharmacology
  • Infectious Diseases

Background:

  • Fluoroquinolones possess broad-spectrum antibacterial activity against Gram-negative and Gram-positive bacteria.
  • These antibiotics are known for excellent oral bioavailability, tissue penetration, low protein binding, and long half-lives.

Purpose of the Study:

  • To compare and contrast the pharmacokinetics of various quinolone antibiotics.
  • To discuss pharmacokinetic considerations in specific populations, including the elderly and patients with renal or hepatic impairment.

Main Methods:

  • Review of pharmacokinetic data for pefloxacin, ciprofloxacin, enoxacin, norfloxacin, ofloxacin, fleroxacin, and lomefloxacin.
  • Analysis of absorption, distribution, metabolism, elimination, and drug/food interactions.

Main Results:

Related Experiment Videos

  • Detailed comparison of pharmacokinetic profiles of selected fluoroquinolones.
  • Discussion of how age and organ impairment affect fluoroquinolone pharmacokinetics.

Conclusions:

  • Fluoroquinolones are essential antibiotics for treating infections.
  • Pharmacokinetic factors are critical for optimizing fluoroquinolone selection in individual patient care.