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Cellular uptake and activity of rufloxacin in different cell types and professional phagocytic cells
1Microbiology Institute, Medical School, University of Messina, Messina, Italy.
International Journal of Antimicrobial Agents
|February 1, 1993
Abstract:
The penetration of the new quinolene rufloxacin into human professional phagocytic cells and different cell types was determined. The intracellular distribution was demonstrated in all cells studied. At 4 degrees C the transport of rufloxacin was reduced. An intracellular dose-dependent activity was demonstrated for rufloxacin in monocytes and granulocytes infected with E. coli and S. aureus. In all the experiments rufloxacin was able to eliminate all intracellular bacteria.

