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The activity 'in vitro' of trospectomycin against high-level antibiotic-resistant enterococci
M Venditti1, A Tarasi, P Baiocchi
1Servizio Aggregato di Consulenze Infettivologiche, Istituto di Clinica, Medica VI, Universita La Sapienza, Rome, Italy.
Abstract:
Trospectomycin, a new aminocyclitol antibiotic, was uniformly active against 69 isolates of enterococci with high-level resistance to steptomycin (54 isolates), gentamicin (27 isolates), ampicillin (19 isolates), ciprofloxacin (17 isolates), vancomycin (3 isolates), or teicoplanin (3 isolates). In time-killing studies, trospectomycin alone demonstrated no bactericidal activity. No synergistic interaction was demonstrated when trospectomycin was combined with ampicillin, vacomycin or ciprofloxacin.
