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Related Concept Videos

Mechanism of Antibiotic Resistance in MRSA01:25

Mechanism of Antibiotic Resistance in MRSA

Antibiotic resistance in bacteria arises when microorganisms evolve the ability to withstand drugs designed to kill them or inhibit their growth, rendering once-effective treatments useless. This phenomenon, driven by genetic change and selection under antibiotic exposure, poses a profound threat to modern medicine. Mechanisms include drug-inactivating enzymes (e.g., β-lactamases), efflux pumps that eject antibiotics, mutations altering antibiotic targets, decreased drug uptake, and acquisition...
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Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...
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Development of Antibiotic Resistance

Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
Antimicrobial Effectiveness01:28

Antimicrobial Effectiveness

The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...
Antibiotic Selection00:57

Antibiotic Selection

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Related Experiment Video

Updated: Jul 3, 2026

Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes
08:58

Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes

Published on: March 3, 2023

Antimicrobial resistance patterns in Korea.

Y Chong1, K Lee, O Hun Kwon

  • 1Department of Clinical Pathology, Yonsei University College of Medicine, Seoul, South Korea.

International Journal of Antimicrobial Agents
|January 1, 1993
PubMed
Summary
This summary is machine-generated.

Antimicrobial resistance is common in Korea, with many bacteria showing resistance to common antibiotics like ampicillin and cephalosporins. However, some specific bacteria, such as Salmonella typhi, remain susceptible to certain treatments.

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Last Updated: Jul 3, 2026

Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes
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Application of the Intelligent High-Throughput Antimicrobial Sensitivity Testing/Phage Screening System and Lar Index of Antimicrobial Resistance
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Area of Science:

  • Microbiology
  • Infectious Diseases
  • Pharmacology

Background:

  • Antimicrobial resistance (AMR) poses a significant global health threat.
  • Understanding regional AMR patterns is crucial for effective treatment strategies.

Purpose of the Study:

  • To investigate the prevalence of antimicrobial resistance in various bacterial pathogens in Seoul, Korea.
  • To identify specific resistance patterns for key bacterial species.

Main Methods:

  • In-vitro susceptibility testing was performed on clinical isolates.
  • Standard microbiological techniques were employed to identify bacterial species and determine resistance profiles.

Main Results:

  • High rates of resistance were observed in aerobic Gram-negative bacilli to ampicillin and first-generation cephalosporins.
  • Significant beta-lactamase production was noted in Moraxella (Branhamella) catarrhalis, Neisseria gonorrhoeae, and Haemophilus influenzae.
  • High resistance levels were found in Streptococcus pneumoniae (penicillin G) and Staphylococcus aureus (methicillin).
  • Enterococcus faecium showed high-level gentamicin resistance, but no vancomycin resistance was detected.
  • Bacteroides fragilis exhibited resistance to clindamycin and cefoxitin.

Conclusions:

  • Antimicrobial-resistant bacteria are prevalent in Korea.
  • Specific resistance patterns necessitate careful antibiotic selection in clinical practice.