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Establishment and Characterization of UTI and CAUTI in a Mouse Model
Published on: June 23, 2015
Complicated urinary tract infections
1Boston University School of Medicine, and Carney Hospital, 2100 Dorchester Avenue, Boston, MA 02124, USA.
Abstract:
No standard definition exists for the term, complicated urinary tract infection. The term is usually used to convey an infection that occurs in a host with altered defenses or in a patient with a structural or functional abnormality impeding urine flow. Therapy of complicated infections represents a greater challenge than treatment of uncomplicated urinary tract infections. Drug treatment of complicated urinary tract infections often must be complemented with radiological/surgical intervention. Trimethoprim-sulfamethoxazole and the newer quinolone compounds are currently the preferred agents for the treatment of complicated urinary tract infections. There exists a dearth of well designed published studies to serve as a resource for treatment guidelines.
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Urinary tract infections (UTIs) are one of the most common urinary system disorders. They are caused by bacteria that enter the urethra and can spread to the bladder resulting in cystitis. Pyelonephritis is the result of a UTI that has ascended to the level of the...

