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Updated: Jul 3, 2026

Protective Efficacy and Pulmonary Immune Response Following Subcutaneous and Intranasal BCG Administration in Mice
Published on: September 19, 2016
The BCG controversy
1Eijkman-Winkler Institute for Medical and Clinical Microbiology, Heidelberglaan 100, 3584 CX Utrecht, Netherlands.
Abstract:
The history of tuberculosis control by vaccination with Bacille Calmette-Guérin (BCG) is reviewed. Use of the vaccine is evaluated in light of conflicting results from trials of BCG efficacy. Explanatinations are suggested for the variations between trials, and the continued use of BCG as a vaccine against tuberculosis is discussed.
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