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In vitro activity of WY-49605, a penem antimicrobial

G M Eliopoulos1, C B Wennersten, G Cole

  • 1Department of Medicine, Deaconess Hospital One Deaconess Road, Boston, MA 02215, USA.

International Journal of Antimicrobial Agents
|July 1, 1995
PubMed

Insights

The novel penem antimicrobial WY-49605 shows strong in vitro activity against many Gram-positive bacteria, including methicillin-susceptible staphylococci and penicillin-susceptible streptococci. It is also effective against Enterobacteriaceae, Enterococcus faecalis, and Bacteroides fragilis.

Area of Science:

  • Microbiology
  • Pharmacology
  • Infectious Diseases

Background:

  • The emergence of antibiotic resistance necessitates the development of new antimicrobial agents.
  • Oral antimicrobial agents are crucial for treating a wide range of bacterial infections.

Purpose of the Study:

  • To evaluate the in vitro antimicrobial activity of the novel penem WY-49605.
  • To compare its activity with existing oral antimicrobial agents against various clinically relevant bacteria.

Main Methods:

  • Minimum inhibitory concentrations (MICs) were determined for WY-49605 and comparator agents against a panel of bacterial isolates.
  • MIC(90) values (concentrations inhibiting 90% of isolates) were calculated and compared.

Main Results:

  • WY-49605 demonstrated potent activity against methicillin-susceptible Staphylococcus (MIC(90) = 0.25 microg/ml) and penicillin-susceptible Streptococcus (MIC(90) <= 0.12 microg/ml).
  • It exhibited comparable or superior activity against other Gram-positive genera versus existing agents.
  • WY-49605 and cefpodoxime were the most active agents against Enterobacteriaceae.
  • Susceptibility was observed for Enterococcus faecalis and Bacteroides fragilis (MIC <= 4 microg/ml).
  • Pseudomonas aeruginosa, Enterococcus faecium, and methicillin-resistant Staphylococcus aureus showed resistance to all tested agents.

Conclusions:

  • WY-49605 is a promising oral penem antimicrobial with broad-spectrum activity against key Gram-positive pathogens and Enterobacteriaceae.
  • Its in vitro profile suggests potential utility in treating infections caused by susceptible bacteria, though resistance was noted in certain strains.

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