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Published on: September 19, 2018

Resistance patterns in Turkey

D Gür1, S Unal, H E Akalin

  • 1Hacettepe University, School of Medicine, Section of Infectious Diseases, Ankara 06100, Turkey.

International Journal of Antimicrobial Agents
|September 1, 1995
PubMed

Insights

Antimicrobial resistance is a significant issue in Turkey, affecting both Gram-positive and Gram-negative bacteria. Urgent control measures are needed to limit antibiotic use and combat rising resistance rates.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Pharmacology

Background:

  • Antimicrobial resistance (AMR) poses a growing global health threat.
  • Turkey faces significant challenges with drug-resistant Gram-positive and Gram-negative bacteria.

Purpose of the Study:

  • To review antimicrobial resistance patterns in clinically significant bacteria in Turkey.
  • To highlight key resistance mechanisms and their prevalence.

Main Methods:

  • Review of existing literature and surveillance data on antimicrobial resistance in Turkey.
  • Analysis of resistance trends in Gram-positive (staphylococci, enterococci, S. pneumoniae) and Gram-negative bacteria (Klebsiella, Salmonella, Pseudomonas).

Main Results:

  • High rates of methicillin resistance in staphylococci (13-37%).
  • Penicillin resistance in S. pneumoniae (47% in one study).
  • Significant aminoglycoside resistance in Gram-negative bacilli, often plasmid-mediated; detection of extended-spectrum beta-lactamases (ESBLs) and specific enzymes like OXA-10 and PER-1.

Conclusions:

  • Urgent need for country-wide implementation of antibiotic control measures.
  • Restriction of antibiotic use is crucial to mitigate resistance spread.
  • Continued surveillance and intervention strategies are essential.

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