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Updated: Jul 3, 2026

The Use of a β-lactamase-based Conductimetric Biosensor Assay to Detect Biomolecular Interactions
Published on: February 1, 2018
Broad-spectrum beta-lactam antibiotics with beta-lactamase inhibitors
P Muñoz1, F García-Garrote, E Bouza
1Department of Clinical Microbiology and Infectious Diseases, Hospital General Universitario 'Gregorio Mararañón', Madrid, Spain.
Abstract:
Combining cefoperazone, piperacillin or ticarcillin with the beta-lactamase inhibitors sulbactam, tazobactam or clavulanic acid, respectively, results in compounds with activity against a wide range of Gram-positive and Gram-negative aerobic and anaerobic organisms, including strains producing beta-lactamases. Pharmacokinetics of the three combinations are similar. Cefoperazone/sulbactam can be given twice daily as opposed to a minimum of three-times-daily dosing required with the other combinations. All 9 combinations have a good safety profile, and may be administered parenterally for the treatment of severe infections in hospitalized patients, including intra-abdominal, gynaecological, skin and soft tissue infections. Additional cover may be provided by administering one of these combinations with an aminoglycoside.
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