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Culturing and Maintaining Clostridium difficile in an Anaerobic Environment

Culturing and Maintaining Clostridium difficile in an Anaerobic Environment

Published on: September 14, 2013

Clostridium difficile infection: a surgical disease in evolution.

Joshua L Hermsen¹, Cosmin Dobrescu, Kenneth A Kudsk

¹Department of Surgery, University of Wisconsin-Madison College of Medicine and Public Health, 600 Highland Avenue, H4/736 CSC, Madison, WI 53792-7375, USA.

Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract

|July 10, 2008

Summary

The incidence of Clostridium difficile colitis is rising alarmingly, with significant increases in hospitalizations. This trend, linked to hospital and operative volumes, necessitates urgent interventions to prevent an epidemic.

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Culturing and Maintaining Clostridium difficile in an Anaerobic Environment

Culturing and Maintaining Clostridium difficile in an Anaerobic Environment

Published on: September 14, 2013

Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291

Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291

Published on: December 10, 2016

Area of Science:

Infectious Diseases
Gastroenterology
Epidemiology

Background:

Recent publications indicate a potential rise in Clostridium difficile colitis incidence.
Concerns exist regarding increasing virulence of C. difficile infections.
Previous studies often lacked adequate denominators to quantify incidence increases.

Purpose of the Study:

To investigate the trend of Clostridium difficile infection (CDI) incidence over time.
To analyze the relationship between CDI cases and hospital, operative, and laboratory volumes.
To assess changes in colectomy rates for CDI.

Main Methods:

Retrospective analysis of billing, admission, operative, and infection databases from 1990 to 2006.
Case numbers of C. difficile infection indexed against hospital, operative, and laboratory volumes.
Individual examination and analysis of C. difficile colectomy cases.

Main Results:

Hospitalized patients diagnosed with C. difficile colitis increased linearly from 14 cases in 1990 to 927 in 2006.
The colectomy per C. difficile case ratio remained stable across study eras (0.17%–0.20%).
Increased CDI admissions significantly correlated with hospital (p=0.04), operative (p<0.001), and lab testing volumes (p=0.008).

Conclusions:

A significant rise in C. difficile patient admissions was observed.
This increase mirrors national trends, suggesting a potential epidemic.
Urgent preventive actions are warranted to address the growing C. difficile burden.