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A New Murine Model of Endovascular Aortic Aneurysm Repair
Published on: July 7, 2013
Vaccination with clumping factor A and fibronectin binding protein A to prevent Staphylococcus aureus infection of an
Carlos Arrecubieta1, Iwao Matsunaga, Tomohiro Asai
1Divisions of Infectious Diseases, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA.
Abstract:
Staphylococcus aureus is a leading cause of ventricular assist device-related infections. This study evaluated the protective effect against S. aureus infection of active and passive immunization that targeted 3 proteins involved in bacterial attachment to a murine intra-aortic polyurethane patch. Active immunization of mice with a combination of the A domains of clumping factor A (ClfA), fibronectin-binding protein A (FnBPA) and fibronectin-binding protein B or passive immunization with monoclonal antibodies against ClfA and FnBPA resulted in a higher level of protection than that obtained by vaccination with either protein or antibody alone. The combination of antibodies or protein antigens appears to provide enhanced protection against prosthetic-device infection.
