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Simultaneous estimation of atorvastatin and ramipril by RP-HPLC and spectroscopy
Lincy Joseph1, Mathew George, Venkata Ranga Rao B
1School of Pharmacy, Mekelle University, Ethiopia. mathewlincg@yahoo.com
Abstract:
A number of analytical methods were reported for the estimation of atorvastatin and ramipril from their individual dosage forms or in combination with other drugs (Valiyare, 2004; Vachareau and Neirinck, 2000). Here successful reverse phase-high performance liquid chromatographic method and spectroscopic methods developed then validated for the analysis of combined dosage form of atorvastatin and ramipril. Individual lambda-max for atorvastatin is 247 n.m and that of ramipril is 208 n.m. They intercept at 215 n.m which is fixed as wavelength for reverse phase-high performance liquid chromatographic method.
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