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Related Concept Videos

Tissue Transplantation01:24

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...
Kidney Transplant III: Nursing Management01:16

Kidney Transplant III: Nursing Management

Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

Overview

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Related Experiment Video

Updated: Jul 3, 2026

Murine Full-thickness Skin Transplantation
07:59

Murine Full-thickness Skin Transplantation

Published on: January 2, 2017

Malignancy after solid organ transplantation: an overview.

S Yousuf Zafar1, David N Howell, Jon P Gockerman

  • 1Divisions of Hematology and Medical Oncology, Duke University Medical Center, 508 Fulton Street (152), Durham, North Carolina 27705, USA. yousuf.zafar@duke.edu

The Oncologist
|July 11, 2008
PubMed
Summary
This summary is machine-generated.

Post-transplant cancers are a growing concern. This report details a rare case of Kaposi's sarcoma (KS) developing in a lung transplant recipient, highlighting the need for vigilance.

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Last Updated: Jul 3, 2026

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Murine Corneal Transplantation: A Model to Study the Most Common Form of Solid Organ Transplantation
09:03

Murine Corneal Transplantation: A Model to Study the Most Common Form of Solid Organ Transplantation

Published on: November 17, 2014

Area of Science:

  • Oncology
  • Immunology
  • Transplantation Medicine

Background:

  • Solid organ transplantation survival rates are improving, leading to increased awareness of long-term complications.
  • Malignancy is a significant post-transplant complication, with nonmelanoma skin cancers, post-transplant lymphoproliferative disorders, and Kaposi's sarcoma (KS) being most common.
  • Immunosuppressive therapy and viral infections are implicated in the pathogenesis of post-transplant cancers.

Observation:

  • This report presents the second documented case of Kaposi's sarcoma (KS) occurring within a lung transplant graft.
  • The patient developed KS in the transplanted lung, a rare occurrence in lung transplant recipients.

Findings:

  • Kaposi's sarcoma (KS) can manifest within the transplanted organ itself.
  • The development of KS post-lung transplantation underscores the complex interplay between immunosuppression, viral reactivation, and oncogenesis.

Implications:

  • Clinicians managing solid organ transplant recipients must maintain a high index of suspicion for post-transplant malignancies, including rare presentations like KS in the graft.
  • Management strategies may involve adjusting immunosuppression, surgical resection, and chemotherapy.
  • Further research is warranted to understand the specific mechanisms driving KS development in transplanted organs.