Emotion-induced retrograde amnesia is determined by a 5-HTT genetic polymorphism
Bryan A Strange1, Marijn C W Kroes, Jonathan P Roiser
1Wellcome Trust Centre for Neuroimaging, Institute of Neurology, London WC1N 3BG, United Kingdom. bstrange@fil.ion.ucl.ac.uk
The short allele of the serotonin transporter (5-HTT) gene influences memory, causing retrograde amnesia for emotional events. This highlights the serotonin system's role in emotion-mediated memory disruption.
Area of Science:
- Neuroscience
- Genetics
- Psychology
Background:
- The serotonin transporter (5-HTT) gene polymorphism is linked to anxiety, depression, and amygdala activity.
- The impact of 5-HTT polymorphism on emotional modulation of human episodic memory remains unclear.
Purpose of the Study:
- To investigate the role of 5-HTT gene polymorphism in the emotional modulation of episodic memory.
- To determine if 5-HTT polymorphism affects emotion-induced memory disruption.
Main Methods:
- Examined the effect of 5-HTT polymorphism on memory recall for aversive events.
- Assessed for emotion-induced retrograde amnesia in relation to 5-HTT genotype.
Main Results:
- Emotional memory for aversive events was not significantly influenced by 5-HTT polymorphism.
- An emotion-induced retrograde amnesia was observed exclusively in individuals with the short 5-HTT allele.
Conclusions:
- The serotonin system plays a crucial role in emotion-mediated memory disruption.
- The short 5-HTT allele is specifically associated with retrograde amnesia for emotional experiences.
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