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Published on: March 15, 2019
Restorative interventions for HIV facial lipoatrophy
Dianne Carey1, Steven Liew, Sean Emery
1National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, Sydney, Australia. dcarey@nchecr.unsw.edu.au
AIDS Reviews
|July 11, 2008
Summary
Facial lipoatrophy in HIV patients can be treated with injectable fillers, offering aesthetic improvement and enhanced quality of life. Further research is needed for optimal treatment strategies.
Area of Science:
- Dermatology
- Infectious Diseases
- Plastic Surgery
Background:
- Facial lipoatrophy is a common, distressing symptom of HIV lipodystrophy, negatively impacting quality of life and treatment adherence.
- Current therapies for facial lipoatrophy are limited, with no proven treatments beyond modest benefits from specific antiretroviral drug cessation.
Purpose of the Study:
- To review the efficacy and safety of biodegradable and permanent filling agents for HIV facial lipoatrophy.
- To discuss challenges in comparing treatment data and assessing outcomes for facial fat restoration.
Main Methods:
- Systematic review of existing clinical studies on soft-tissue augmentation for HIV facial lipoatrophy.
- Analysis of efficacy and safety data for various biodegradable and permanent fillers.
Main Results:
- Most available filling agents demonstrate short-term clinical safety in HIV-infected adults.
- Injectable fillers can provide aesthetic improvements, enhancing well-being, social functioning, and quality of life.
Conclusions:
- While fillers offer short-term benefits for HIV facial lipoatrophy, robust clinical studies with objective endpoints are necessary.
- Optimal, long-term treatment strategies for this condition require further investigation.