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Related Concept Videos

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
Diabetic Neuropathy01:22

Diabetic Neuropathy

DefinitionDiabetic neuropathy is nerve damage caused by long-standing diabetes mellitus. It results directly from prolonged high blood sugar levels.PathophysiologyThe pathophysiology of diabetic neuropathy involves both metabolic and vascular disturbances triggered by chronic hyperglycemia.Metabolic injury: Elevated glucose levels activate the polyol pathway within nerve cells, leading to the accumulation of sorbitol and fructose. This increases oxidative stress, disrupts normal nerve...
Peripheral Artery Disease IV: Nursing Management01:26

Peripheral Artery Disease IV: Nursing Management

The nursing management of a patient with peripheral artery disease (PAD) begins with a thorough assessment of the patient’s health history and clinical manifestations.AssessmentHealth History: Evaluate the patient’s history of hypertension, hyperlipidemia, family history of cardiovascular issues, and lifestyle factors such as dietary patterns, smoking, and physical activity.Physical Examination:Assess the affected extremity for decreased or absent peripheral pulses, temperature changes,...
Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
Local Anesthetics: Differential Sensitivity of Nerve Fibers01:24

Local Anesthetics: Differential Sensitivity of Nerve Fibers

Local anesthetics (LAs) block the sodium channels of nerve trunks, sensory nerve endings, and neuromuscular junctions. Although LAs can block all kinds of nerves, the sensitivity of nerve fibers differs according to nerve types and structures. LAs are known to block myelinated fibers faster than unmyelinated ones. Also, they block pain or sensory neurons at low concentrations without affecting the motor neurons involved in muscle contractions. This helps relieve labor pain without affecting the...
Peripheral Artery Disease V: Postoperative Nursing Management01:23

Peripheral Artery Disease V: Postoperative Nursing Management

During the postoperative period, it is crucial to focus on maintaining circulation, identifying and managing potential complications, and planning for discharge.Nursing AssessmentVital signs monitoring: Regularly monitor vital signs, including blood pressure, heart rate, respiratory rate, and temperature, to detect early signs of complications such as bleeding and infection.Circulation assessment: Monitor pulses, perform Doppler assessments, and check capillary refill, color, temperature, and...

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Related Experiment Video

Updated: Jul 3, 2026

Establishing a Mouse Model of a Pure Small Fiber Neuropathy with the Ultrapotent Agonist of Transient Receptor Potential Vanilloid Type 1
09:39

Establishing a Mouse Model of a Pure Small Fiber Neuropathy with the Ultrapotent Agonist of Transient Receptor Potential Vanilloid Type 1

Published on: February 13, 2018

Painful peripheral neuropathies.

P Marchettini1, M Lacerenza, E Mauri

  • 1Pain Medicine Center, Scientific Institute San Raffaele, Via Stamira D'Ancona 20, 20127 Milano, Italy. marchettini.paolo@hsr.it

Current Neuropharmacology
|July 11, 2008
PubMed
Summary
This summary is machine-generated.

Peripheral neuropathies cause debilitating pain, often misdiagnosed. Understanding nerve anatomy and pathophysiology is key for accurate diagnosis and effective treatment of neuropathic pain.

Keywords:
Paindiabetic neuropathyhereditary neuropathyneuropathicparaneoplastic polyneuropathypolyneuropathypost herpetic neuralgiasmall fibres neuropathy

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Regenerative Peripheral Nerve Interface: Surgical Protocol for a Randomized Controlled Trial in Postamputation Pain
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Regenerative Peripheral Nerve Interface: Surgical Protocol for a Randomized Controlled Trial in Postamputation Pain

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Establishing a Mouse Model of a Pure Small Fiber Neuropathy with the Ultrapotent Agonist of Transient Receptor Potential Vanilloid Type 1
09:39

Establishing a Mouse Model of a Pure Small Fiber Neuropathy with the Ultrapotent Agonist of Transient Receptor Potential Vanilloid Type 1

Published on: February 13, 2018

Regenerative Peripheral Nerve Interface: Surgical Protocol for a Randomized Controlled Trial in Postamputation Pain
03:53

Regenerative Peripheral Nerve Interface: Surgical Protocol for a Randomized Controlled Trial in Postamputation Pain

Published on: March 15, 2024

Area of Science:

  • Neurology
  • Pain Medicine

Background:

  • Peripheral neuropathies are diverse diseases affecting nerves, with varied causes and timelines.
  • While often causing weakness and sensory loss, intense pain is a common and disabling symptom.

Purpose of the Study:

  • To highlight the diagnostic challenges and treatment delays for neuropathic pain.
  • To elucidate the mechanisms underlying neuropathic pain generation.
  • To emphasize the importance of understanding nerve anatomy for effective pain management.

Main Methods:

  • Review of peripheral neuropathy pathophysiology and pain mechanisms.
  • Analysis of clinical observations linking small fiber neuropathy to pain.
  • Comparison of neuropathic and nociceptive pain descriptions.

Main Results:

  • Neuropathic pain often stems from small fiber pathology or abnormal nociceptive afferent activity.
  • Nerve trunk pain can herald inflammatory or ischemic mononeuropathy and is a medical emergency.
  • Patients describe neuropathic pain as pins and needles, burning, or tingling, distinct from nociceptive pain's deep, dull ache.

Conclusions:

  • Accurate recognition of neuropathic pain components is crucial.
  • Targeted treatment based on pain intensity, type, and temporal profile improves patient outcomes.
  • Expertise in peripheral nerve anatomy and pathophysiology is essential for timely and effective management.