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Sarcopenia: its assessment, etiology, pathogenesis, consequences and future perspectives.
Y Rolland1, S Czerwinski, G Abellan Van Kan
1Inserm U558, F-31073Toulouse, France. rolland.y@chu-toulouse.fr
The Journal of Nutrition, Health & Aging
|July 11, 2008
Summary
Sarcopenia, the age-related loss of muscle mass and function, is a key factor in frailty. Understanding its causes and effects is crucial for developing new treatments to combat mobility loss in aging populations.
Area of Science:
- Gerontology
- Muscle Physiology
- Aging Research
Background:
- Sarcopenia is characterized by the loss of muscle protein mass and function.
- It is a significant contributor to the development of frailty in older adults.
Purpose of the Study:
- To provide a comprehensive review of current knowledge on sarcopenia.
- To discuss its assessment, etiology, pathogenesis, and consequences.
- To explore future perspectives and ongoing research in sarcopenia.
Main Methods:
- This study is a review of existing literature and research on sarcopenia.
- It synthesizes information on the multifaceted aspects of sarcopenia.
Main Results:
- Sarcopenia is a complex condition associated with aging and frailty.
- Current understanding covers its various biological and clinical dimensions.
Conclusions:
- Ongoing and future clinical trials hold the potential to significantly alter preventive and therapeutic strategies for sarcopenia.
- These advancements may lead to improved management of mobility disability in the elderly.
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