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MASPIN tumour-suppressing activity in head and neck squamous cell carcinoma: emerging evidence and therapeutic

Gino Marioni1, Claudia Staffieri, Alberto Staffieri

  • 1Department of Medical and Surgical Specialties, Section of Otolaryngology, University of Padova, Padova, Italy. gino.marioni@unipd.it

Acta Oto-Laryngologica
|July 11, 2008
PubMed
Abstract

Insights

MASPIN (MFS-1) expression in head and neck squamous cell carcinoma (HNSCC) may predict patient outcomes. Low cytoplasmic MASPIN correlates with metastasis in oral SCC, while nuclear MASPIN indicates better prognosis in laryngeal SCC.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • MASPIN (MFS-1) is a serpin with demonstrated tumor-suppressing activity.
  • Head and neck squamous cell carcinoma (HNSCC) has a significant incidence, yet MASPIN's role in these malignancies is under-explored.
  • This review explores translating MASPIN's potential into diagnostic, prognostic, and therapeutic applications for HNSCC.

Purpose of the Study:

  • To review the literature on MASPIN's subcellular localization and biological function in HNSCC.
  • To assess MASPIN's potential as a diagnostic and prognostic marker in HNSCC.
  • To evaluate MASPIN-targeted therapies for HNSCC.

Main Methods:

  • A systematic literature review was conducted.
  • Evidence regarding MASPIN's subcellular localization and biological role in HNSCC was investigated.
  • Studies on MASPIN expression in oral and laryngeal SCC were analyzed.

Main Results:

  • Low or absent cytoplasmic MASPIN expression is more frequent in oral SCC with lymph node metastases.
  • Higher nuclear MASPIN expression in laryngeal SCC is associated with longer disease-free survival and reduced micro-vascular density.
  • Nuclear MASPIN expression in laryngeal SCC correlates with increased apoptosis, suggesting a sensitizing effect.

Conclusions:

  • Elective neck dissection may be considered for cN0 oral SCC patients with MASPIN-negative status.
  • Re-activated nuclear MASPIN, combined with anti-angiogenic or cytotoxic drugs, holds promise for treating laryngeal SCC.

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