Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Batch vs Continuous Culture

Batch vs Continuous Culture

Fermentation is a foundational biotechnological process used to produce pharmaceuticals, biofuels, enzymes, and food additives. Among industrial strategies, batch and continuous fermentation are the two most widely applied. Although both rely on microbial conversion of substrates into desired products, they differ markedly in operation, productivity, and suitability for specific applications.Batch fermentation occurs in a closed system in which nutrient media and inoculum are added at the...

Drug Accumulation During Multiple Dosing: Intermittent IV Infusions

Drug Accumulation During Multiple Dosing: Intermittent IV Infusions

Intermittent intravenous (IV) infusion is a method of drug administration where medications are delivered over short infusion periods followed by intervals of no drug delivery. This approach helps to prevent sustained high drug concentrations in the bloodstream, reducing the risk of adverse effects associated with prolonged exposure. Unlike continuous infusion, steady-state concentrations may not be achieved during a single dosing cycle but can be reached through repeated...

Nature and Nurture

Nature and Nurture

Many human characteristics, like height, are shaped by both nature—in other words, by our genes—and by nurture, or our environment. For example, chronic stress during childhood inhibits the production of growth hormones and consequently reduces bone growth and height. Scientists estimate that 70-90% of variation in height is due to genetic differences among individuals, and 10-30% of variation in height is due to differences in the environments that individuals experience, such as differences...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Photobiomodulation in the infrared spectrum reverses the expansion of circulating natural killer cells and brain microglial activation in Sanfilippo mice.

Journal of neurochemistry·2024

Same author

Childhood Adversity and the Creative Experience in Adult Professional Performing Artists.

Frontiers in psychology·2018

Same author

Effects of 25-hydroxycholecalciferol with two D<sub>3</sub> vitamin levels on production and immunity parameters in broiler chickens.

Journal of animal physiology and animal nutrition·2017

Same author

Training-induced Increase in Bone Mineral Density between Growing Male and Female Rats.

International journal of sports medicine·2015

Same author

Leukemic stem cells: a review.

Cancer investigation·2013

Same author

Different training volumes yield equivalent increases in BMD.

International journal of sports medicine·2010

Search research articles

Related Experiment Video

Updated: Jul 3, 2026

Tricolor Transgenic Murine Model for Studying Growth Plate Injury

Tricolor Transgenic Murine Model for Studying Growth Plate Injury

Published on: September 6, 2024

Interrupted vs. uninterrupted training on BMD during growth.

B M Goettsch¹, M Z Smith, J A O'Brien

¹Department of Biological Sciences, Chapman University, Orange, California 92866, United States.

International Journal of Sports Medicine

|July 11, 2008

Summary

Both interrupted and uninterrupted resistance training equally enhance bone modeling and bone mineral density (BMD) in young animals. This study found no significant difference between continuous repetitions versus multiple daily sessions for improving bone health markers.

More Related Videos

Improved Methodology for Studying Postnatal Osteogenesis via Intramembranous Ossification in a Murine Bone Marrow Injury Model

Improved Methodology for Studying Postnatal Osteogenesis via Intramembranous Ossification in a Murine Bone Marrow Injury Model

Published on: February 7, 2025

Related Experiment Videos

Last Updated: Jul 3, 2026

Tricolor Transgenic Murine Model for Studying Growth Plate Injury

Tricolor Transgenic Murine Model for Studying Growth Plate Injury

Published on: September 6, 2024

Improved Methodology for Studying Postnatal Osteogenesis via Intramembranous Ossification in a Murine Bone Marrow Injury Model

Improved Methodology for Studying Postnatal Osteogenesis via Intramembranous Ossification in a Murine Bone Marrow Injury Model

Published on: February 7, 2025

Area of Science:

Exercise Physiology
Bone Biology
Animal Models

Background:

Resistance training is crucial for bone health.
Understanding optimal training protocols for bone modeling is important.
Previous research has not directly compared interrupted versus uninterrupted resistance training for bone outcomes.

Purpose of the Study:

To compare the effects of uninterrupted (UT) versus interrupted (IT) resistance training on bone modeling and bone mineral density (BMD).
To determine if training session structure influences bone adaptation in maturating animals.

Main Methods:

24 young male rats were divided into Control, UT, and IT groups.
UT and IT groups performed ladder climbing with weights 3 days/wk for 6 weeks.
Bone modeling markers (serum osteocalcin, urinary deoxypyridinoline [DPD]) and tibial BMD were assessed.

Main Results:

Both UT and IT resistance training significantly reduced urinary DPD compared to controls.
Tibial BMD was significantly higher in both UT and IT groups versus controls.
No significant differences in DPD or BMD were observed between the UT and IT groups.

Conclusions:

Both interrupted and uninterrupted resistance training programs are equally effective in stimulating bone modeling.
The structure of resistance training sessions (continuous vs. interrupted) does not appear to impact bone adaptation when total work volume is equivalent.