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Related Concept Videos

Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Obesity01:24

Obesity

The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in adipocytes...
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Essential Minerals for Bone Health01:31

Essential Minerals for Bone Health

The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...

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Using Real-Time Cell Metabolic Flux Analyzer to Monitor Osteoblast Bioenergetics
09:43

Using Real-Time Cell Metabolic Flux Analyzer to Monitor Osteoblast Bioenergetics

Published on: March 1, 2022

[Obesity and bone metabolism].

Michał Holecki1, Barbara Zahorska-Markiewicz, Andrzej Wiecek

  • 1Katedra Patofizjologii, Slaski Uniwersytet Medyczny, Katowice. holomed@poczta.onet.pl

Endokrynologia Polska
|July 11, 2008
PubMed
Summary

Obesity may protect bone tissue, but research is mixed on its effect on osteoporosis fractures. This article explores the complex relationship between adipose tissue and bone metabolism.

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Osteoclast Derivation from Mouse Bone Marrow
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Using Real-Time Cell Metabolic Flux Analyzer to Monitor Osteoblast Bioenergetics
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Using Real-Time Cell Metabolic Flux Analyzer to Monitor Osteoblast Bioenergetics

Published on: March 1, 2022

Osteoclast Derivation from Mouse Bone Marrow
06:17

Osteoclast Derivation from Mouse Bone Marrow

Published on: November 6, 2014

Area of Science:

  • Biomedical Science
  • Endocrinology
  • Metabolism

Context:

  • Bone and adipose tissue undergo dynamic changes throughout life.
  • Genetic, hormonal, and neural factors influence these tissue modifications.
  • The interplay between obesity and bone health is a subject of ongoing scientific debate.

Purpose:

  • To elucidate the relationship between adipose tissue and bone metabolism.
  • To discuss the conflicting findings regarding obesity's impact on bone health.
  • To provide a comprehensive overview of current research on this topic.

Summary:

  • Adipose tissue, or body fat, plays a significant role in regulating bone metabolism.
  • While obesity is often considered protective for bone, some studies suggest it may not prevent osteoporosis-related fractures.
  • Understanding these complex interactions is crucial for bone health management.

Impact:

  • This review offers valuable insights for researchers and clinicians studying bone diseases and metabolic disorders.
  • It highlights the need for further investigation into the mechanisms linking fat tissue and bone health.
  • The findings can contribute to developing targeted strategies for preventing and treating osteoporosis.