Related Experiment Video
Updated: Jul 3, 2026
Fabrication of Size-Controlled and Emulsion-Free Chitosan-Genipin Microgels for Tissue Engineering Applications
Published on: April 13, 2022
Nanocomposites of genipin-crosslinked chitosan/silver nanoparticles--structural reinforcement and antimicrobial
Bai-Shuan Liu1, Tsung-Bin Huang
1Department of Medical Imaging and Radiological Science, Central Taiwan University of Science and Technology, Taichung, Taiwan. bsliu@ctust.edu.tw
Abstract:
This study investigates the feasibility of a novel nanocomposite (GC/Ag) of a genipin-crosslinked chitosan (GC) film in which was embedded various amounts of Ag nanoparticles for wound-dressing applications. In situ UV-vis results revealed that adding chitosan solution did not affect the characteristics of Ag nanoparticles. The water uptake ratios and surface hydrophilicity of the GC/Ag nanocomposite were better and the degradation rates slightly lower than those of the pure GC film. The presence of Ag nanoparticles enhanced L929 cell attachment and growth. Its function as an anti-microbial agent in a GC/Ag nanocomposite was assessed for Ag contents of over 100 ppm. In conclusion, silver ions had dual functions--structural reinforcement and provision of antimicrobial properties to a biocompatible polymer.
