Related Experiment Video
Updated: Jul 3, 2026
07:29
Comprehensive Characterization of Tissue Mineralization in an Ex Vivo Model
Published on: September 27, 2024
Mini-review: Osteoblasts: An in vitro model of bone-implant interactions
1Department of Biomedical Engineering, Rensselaer Polytechnic Institute, Troy, New York 12180-3590.
Biotechnology and Bioengineering
|March 25, 1994
Abstract:
Well-characterized osteoblasts provide a successful in vitro model to study bone-biomaterial interactions. Knowledge of the events occurring at this tissue-biomaterial interface could lead to the design of improved orthopedic/dental biomaterials which elicit specific and desirable responses from surrounding cells/tissues, optimize function of osteoblasts (the boneforming cells), and enhance long-term bone-implant bonding. (c) 1994 John Wiley & Sons, Inc.
Related Concept Videos
01:31Osteoclasts in Bone Remodeling
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
01:40Bone Remodeling
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.