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Related Experiment Video

Updated: Jul 3, 2026

Fabrication of Size-Controlled and Emulsion-Free Chitosan-Genipin Microgels for Tissue Engineering Applications

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Published on: April 13, 2022

Chitosan microparticles as injectable scaffolds for tissue engineering.

Dunia Mercedes García Cruz¹, Jorge Luis Escobar Ivirico, Manuela M Gomes

¹Centre for Biomaterials, Universidad Politécnica de Valencia, 46022 Valencia, Spain.

Journal of Tissue Engineering and Regenerative Medicine

|July 11, 2008

Summary

Injectable chitosan microparticles offer a promising scaffold for cell transplantation. This study demonstrates their feasibility in creating 3D constructs with goat bone marrow stromal cells for tissue engineering.

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Last Updated: Jul 3, 2026

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Published on: April 13, 2022

Constructing a Collagen Hydrogel for the Delivery of Stem Cell-loaded Chitosan Microspheres

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Synthesis of Thermogelling Poly(N-isopropylacrylamide)-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering

Published on: October 26, 2016

Area of Science:

Biomaterials Science
Tissue Engineering
Regenerative Medicine

Background:

Traditional 3D scaffolds for cell transplantation have limitations.
Injectable carriers offer a potential solution to overcome these drawbacks.

Purpose of the Study:

To evaluate chitosan microparticles as injectable carriers for cell transplantation.
To assess the feasibility of creating 3D constructs using chitosan microparticles and goat bone marrow stromal cells (GBMCs).

Main Methods:

Chitosan microparticles were crosslinked with genipin.
A 3D construct was formed in vitro by combining crosslinked chitosan microparticles with GBMCs.
Cell viability and morphology of GBMCs were assessed after 7 and 14 days of culture.

Main Results:

The combination of chitosan microparticles and GBMCs successfully formed a 3D construct in vitro.
GBMCs maintained viability and exhibited favorable morphology after 7 and 14 days of culture within the chitosan microparticle construct.

Conclusions:

Chitosan microparticles are a feasible material for creating injectable scaffolds.
These injectable scaffolds show potential for applications in tissue engineering and regenerative medicine.