Nanomechanical assay to investigate the selectivity of binding interactions between volatile benzene derivatives
Digvijay Raorane1, Si-Hyung Shawn Lim, Arun Majumdar
1Department of Mechanical Engineering, University of California, Berkeley, Berkeley, California 94704, USA.
Abstract:
Understanding the interactions between aromatic gas molecules and various simple aromatic receptor molecules is important in developing selective receptors for volatile organic compounds (VOCs). Here, five benzene thiols with different functional end groups were used to investigate the weak binding of aromatic vapors such as dinitrotolouene (DNT) and toluene. A multiplexed microcantilever array in conjunction with a very low concentration vapor generation system was developed to study multiple receptor-target interactions simultaneously. Differential nanomechanical responses of such devices provided insight into the influence of various chemical and structural features of such molecules.
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