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Updated: Jul 3, 2026

Pairwise Growth Competition Assay for Determining the Replication Fitness of Human Immunodeficiency Viruses
Published on: May 4, 2015
Mathematical analysis of a HIV model with frequency dependence and viral diversity
Shingo Iwami1, Shinji Nakaoka, Yasuhiro Takeuchi
1Graduate School of Science and Technology, Shizuoka University, Hamamatsu, Japan. f5745020@ipc.shizuoka.ac.jp
Abstract:
We consider the effect of viral diversity on the human immune system with the frequency dependent proliferation rate of CTLs and the elimination rate of infected cells by CTLs. The model has very complex mathematical structures such as limit cycle, quasi-periodic attractors, chaotic attractors, and so on. To understand the complexity we investigate the global behavior of the model and demonstrate the existence and stability conditions of the equilibria. Further we give some theoretical considerations obtained by our mathematical model to HIV infection.
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