Related Experiment Video
Updated: Jul 3, 2026

Determination of the Relative Potency of an Anti-TNF Monoclonal Antibody (mAb) by Neutralizing TNF Using an In Vitro Bioanalytical Method
Published on: September 16, 2017
Anti-TNF-alpha therapies in chronic obstructive pulmonary diseases
Sabina A Antoniu1, Florin Mihaltan, Ruxandra Ulmeanu
1'Gr.T.Popa' University of Medicine and Pharmacy Iasi, Division of Pulmonary Disease, Pulmonary Disease University Hospital, 30 Dr I Cihac Street, 700115 Iasi, Romania. sabina.antonela.antoniu@pneum.umfiasi.ro
Background:
Chronic obstructive pulmonary disease (COPD) and asthma are chronic diseases in which inflammation of the airways leads to progressive transient airway obstruction and TNF-alpha plays an important pro-inflammatory role.
Objective:
To assess the plausibility of anti-TNF-alpha therapies playing an anti-inflammatory role in asthma and COPD.
Methods:
Scientific rationale of TNF-alpha targeting in asthma and COPD was assessed individually and the available data on the use of anti-TNF-alpha in each disease were reviewed.
Results And Conclusion:
Anti-TNF-alpha therapies demonstrate different efficacies in asthma and COPD and further supportive preclinical and clinical data are needed, especially about subsets of certain diseases which could benefit the most from these therapies.
Related Concept Videos
Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF
COPD: Management Using Bronchodilators and Corticosteroids
Chronic Obstructive Pulmonary Disease-V: Management
Smoking Cessation
Drugs Used in Lower Respiratory Disorders: Overview
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
Chronic Obstructive Pulmonary Disease-II: Pathophysiology
Chronic Inflammation
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...