Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jul 3, 2026

Strategies for Assessing Autistic-Like Behaviors in Mice
07:38

Strategies for Assessing Autistic-Like Behaviors in Mice

Published on: September 20, 2024

Behavioral characterization of P311 knockout mice.

Gregory A Taylor1, Ramona M Rodriguiz, Robert I Greene

  • 1Geriatric Research, Education, and Clinical Center, VA Medical Center, Durham, NC, USA.

Genes, Brain, and Behavior
|July 12, 2008
PubMed
Summary

The protein P311 is crucial for normal brain function, impacting learning, memory, and emotional responses in mice. Its absence leads to significant behavioral alterations, highlighting its importance in neural development and cognition.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Role of endothelial Dlc1 in embryonic vascular development and adult bone marrow hematopoiesis.

Leukemia·2026
Same author

Irgm1 Restrains CD8<sup>+</sup> T Cell Cytokine Production and Apoptosis via Cell-Extrinsic Regulation of Type I Interferon Signaling.

European journal of immunology·2026
Same author

Large Library Docking for Polypharmacology.

Journal of medicinal chemistry·2026
Same author

BRAF V600E Expression in c-Kit+ Interstitial Cells of Cajal Drives Gastrointestinal Stromal Tumor Formation in Mice.

Cancer research communications·2026
Same author

Electrical stimulation of the vagus nerve improves amyloid pathology in delirium superimposed on dementia.

Bioelectronic medicine·2026
Same author

A single BRCA2 BRC repeat supports viability while multiple repeats ensure resilience under stress.

bioRxiv : the preprint server for biology·2026

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Behavioral Science

Background:

  • P311 is an 8-kDa protein found in various brain regions, including the hippocampus and cerebellum.
  • Its expression is tightly regulated by physiological stimuli, suggesting a role in neural development.
  • The precise function of P311 in normal brain physiology remains unclear.

Purpose of the Study:

  • To investigate the role of P311 in normal brain physiology and behavior.
  • To characterize the behavioral phenotype of P311-deficient mice.

Main Methods:

  • Gene targeting was used to create P311-deficient mice.
  • Behavioral assessments included tests for motor coordination, balance, sensory discrimination, learning, memory, and emotional responses.

More Related Videos

Assessment of Social Interaction Behaviors
06:41

Assessment of Social Interaction Behaviors

Published on: February 25, 2011

Light/dark Transition Test for Mice
10:35

Light/dark Transition Test for Mice

Published on: November 13, 2006

Related Experiment Videos

Last Updated: Jul 3, 2026

Strategies for Assessing Autistic-Like Behaviors in Mice
07:38

Strategies for Assessing Autistic-Like Behaviors in Mice

Published on: September 20, 2024

Assessment of Social Interaction Behaviors
06:41

Assessment of Social Interaction Behaviors

Published on: February 25, 2011

Light/dark Transition Test for Mice
10:35

Light/dark Transition Test for Mice

Published on: November 13, 2006

Main Results:

  • P311-deficient mice exhibited no overt physical abnormalities, normal breeding, and survival rates.
  • No deficits were observed in motor coordination, balance, hearing, or olfactory discrimination.
  • Mutant mice displayed impaired learning and memory in tasks like social transmission of food preference and the Morris water maze.
  • Altered emotional responses were noted, including reduced freezing behavior in fear conditioning and fear-potentiated startle.

Conclusions:

  • P311 plays a significant role in learning and memory processes.
  • P311 is essential for normal emotional responses.
  • These findings establish P311 as a key protein in cognitive and emotional regulation within the brain.