Related Experiment Video
Updated: Jul 3, 2026

Using the Activity-based Anorexia Rodent Model to Study the Neurobiological Basis of Anorexia Nervosa
Published on: October 22, 2015
Brain endocannabinoid system is involved in fluoxetine-induced anorexia
Jon Zarate1, Itziar Churruca, Jesús Pascual
1Department of Physiology, Faculty of Pharmacy, University of the Basque Country, Vitoria-Gasteiz, Spain. jon.zarate@ehu.es
Abstract:
In order to describe the effects of chronic fluoxetine administration on the brain endocannabinoid system in lean and obese Zucker rats, brain immunostaining for the CB1 and CB1-phosphorylated cannabinoid receptors was carried out. Obese Zucker rats showed significantly increased the numbers of neural cells positively immunostained for the CB1-phosphorylated receptor in the striatum, compared to their lean litter-mates. Chronic fluoxetine administration decreased the number of neural cells immunostained for CB1-phosphorylated receptor in several striatal and hippocampal regions of obese Zucker rats, compared to controls treated with saline. In contrast, no change in CB1-phosphorylated receptor immunostaining was observed in fluoxetine-treated lean rats, with respect to controls. Taken together, these results suggest the involvement of the hippocampal and striatal endocannabinoid receptor system in fluoxetine-induced anorexia in lean and obese Zucker rats.
Related Concept Videos
Antidepressant Drugs: MAOIs and Other Agents
Regulation of Food Intake
Chemotherapy-Induced Nausea and Vomiting: Cannabinoids
Two synthetic agonists of THC,...
Antidepressant Drugs: Overview
Antidepressant Drugs: Tricyclics, SSRIs, and SNRIs
Drugs Affecting GI Tract Motility: Serotonin Receptor Agonists
