Elective single embryo transfer versus double embryo transfer in assisted reproduction

Area of Science:

• Reproductive Medicine
• Obstetrics & Gynecology
• Embryology

Background:

• High embryo transfer numbers in assisted reproduction correlate with increased twinning and multiple gestations.
• Single embryo transfer (SET) may offer lower first-cycle success but comparable cumulative live birth rates.

Purpose of the Study:

• To compare the effectiveness of elective single embryo transfer (SET) versus double embryo transfer (DET) in young women undergoing assisted reproduction.
• To evaluate live birth, clinical pregnancy, and multiple pregnancy rates over a 1-year follow-up period.

Main Methods:

• A prospective randomized controlled trial comparing SET and DET in young women.
• Follow-up of participants for 1 year, including cryo-embryo transfer cycles.

Main Results:

• No significant difference in live birth probability between SET and DET groups.
• Significantly higher twin rates observed in the double embryo transfer (DET) group.
• Similar live birth, clinical pregnancy, and multiple pregnancy rates during the 1-year follow-up.

Conclusions:

• Elective single embryo transfer (SET) is a recommended first-line treatment for young women undergoing assisted reproduction due to similar live birth rates and reduced multiple pregnancies.
• Larger randomized studies are needed to confirm these findings.