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Tumor Transplantation for Assessing the Dynamics of Tumor-Infiltrating CD8+ T Cells in Mice
Published on: June 12, 2021
[Effect of yupingfengsan on the growth of tumor and immunological function in tumor-bearing mice]
Hong-Jun Zhang1, Xiao-Yun Tang, Bao-Ling Ju
1Department of Pathogenic Biology, Mudanjiang Medical College, Mudanjiang 157011, China. zhanghj33@yahoo.com.cn
Aim:
To explore the effect of yupingfengsan on the growth of tumor and immunological function in tumor-bearing mice.
Methods:
The models of tumor-bearing mice were established by inoculating the healthy mice with S180 tumor carneus cells cultured in vitro. Then the ratio of tumor restriction was calculated. The phagocytosis activity of phagocytes, the level of NO secreted by phagocytes, the proliferating activity of T lymphocytes and the level of IL-2 were detected in the mice after being treated with yupingfengsan 12 days.
Results:
yupingfengsan elevated the phagocytosis of phagocytes and the level of NO secreted by phagocytes. It promoted T lymphocytes to transform, and increased the level of IL-2 and the activity of NK cells.
Conclusion:
yupingfengsan can increase the immunological function of tumor-bearing mice and suppress the development of tumor in mice.
