Related Experiment Video
Updated: Jul 3, 2026
06:14
Modeling Human Cerebellar Development In Vitro in 2D Structure
Published on: September 16, 2022
Cadherin-6 gene regulatory patterns in the postnatal mouse brain
Yukiko U Inoue1, Junko Asami, Takayoshi Inoue
1Department of Biochemistry and Cellular Biology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Ogawahigashi 4-1-1, Kodaira, Tokyo 187-8502, Japan.
Molecular and Cellular Neurosciences
|July 12, 2008
Summary
Researchers identified specific DNA segments controlling Cadherin-6 (Cdh6) expression in the mouse brain. These regulatory modules are organized by functional connectivity, aiding brain circuit development.
Area of Science:
- Neuroscience
- Molecular Biology
- Developmental Biology
Background:
- Cadherin-6 (Cdh6) is a synaptic adhesion molecule crucial for defining neuronal circuitries in the postnatal mouse brain.
- The precise genetic mechanisms governing Cdh6 expression within functional brain circuits remain largely unknown.
Purpose of the Study:
- To investigate the genetic control of Cadherin-6 expression in the developing mouse brain.
- To identify specific genomic regions responsible for differential Cdh6 expression in distinct brain regions and nuclei.
Main Methods:
- Utilized a method for systematic integration of reporter cassettes into bacterial artificial chromosomes covering the Cdh6 gene locus.
- Evaluated reporter activities in stable transgenic mouse lines to identify regulatory elements.
Main Results:
- Discovered divisible genomic segments that differentially control Cdh6 expression in specific brain regions and nuclei.
- Identified separable regulatory modules for Cdh6 expression that are grouped by functional connectivity.
Conclusions:
- Genetic control of Cdh6 expression is modular and spatially regulated during brain circuit formation.
- The organization of these regulatory modules suggests a role in the developmental and evolutionary elaboration of brain circuitry.
