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Morbidity and mortality among heart failure patients in Galicia, N.W. Spain: the GALICAP Study
Fernando Otero-Raviña1, Lilian Grigorian-Shamagian, Luis Fransi-Galiana
1Sección de Coordinación Asistencial, SERGAS, Santiago de Compostela, Spain.
Insights
Heart failure (HF) patients in Galicia face high mortality and morbidity. Previous cardiovascular hospitalizations are the strongest predictor of adverse outcomes in these heart failure patients.
Area of Science:
- Cardiology
- Public Health
- Epidemiology
Background:
- Heart failure (HF) poses a significant burden on healthcare systems globally.
- Understanding regional variations in HF outcomes is crucial for targeted interventions.
Purpose of the Study:
- To characterize the current morbidity and mortality of heart failure (HF) outpatients in Galicia, Spain.
- To identify the main determinants of adverse outcomes in this population.
Main Methods:
- A prospective, multicenter study was conducted involving 1195 heart failure (HF) outpatients.
- Data were collected by 149 primary care physicians across Galicia.
- Survival rates were analyzed using Cox's proportional hazard model over a mean follow-up of 6.5 months.
Main Results:
- The average patient age was 76 years, with 82% having a history of arterial hypertension.
- Mortality was 8% and hospital readmission was 29% during follow-up, with most events being cardiac-related.
- Independent predictors of cardiovascular death and/or readmission included ischaemic cardiopathy, stroke, oedema, anaemia, deteriorated systolic function, and prior cardiovascular admissions.
Conclusions:
- Morbidity and mortality rates remain high among heart failure (HF) patients in Galicia.
- Previous hospitalization for cardiovascular reasons is the most significant predictor of poor outcomes in HF patients.
Objective:
Characterization of current morbidity and mortality among heart failure (HF) outpatients in Galicia (N.W. Spain), together with their main determinants.
Design:
Prospective multicentre study involving 149 primary care physicians.
Setting:
Primary care physicians selected randomly from among all (1959) primary care physicians in Galicia.
Patients:
Clinical and epidemiological information for 1195 outpatients with HF were collected in 2006, with a mean follow-up of 6.5+/-1.5 months.
Main Outcome Measures:
Survival rates were calculated by Cox's proportional hazard model.
Results:
Mean patient age was 76 years, 48% were male, 82% had a history of arterial hypertension, and 32% ischaemic cardiopathy. Echocardiography had been performed in 67%, showing preserved systolic function in 61%. Ninety-two (8%) died during follow-up [74 (80%) of them from cardiac causes], and 313 (29%) were re-admitted to hospital [230 (73%) of them for cardiac reasons]. Multivariate analysis identified the following independent predictors of cardiovascular death and/or readmission: ischaemic cardiopathy [hazard ratio (HR) 1.76, 95% confidence interval (CI) 1.29-4.40], stroke (HR 1.79, CI 1.18-2.73), oedema (HR 1.49, CI 1.10-2.03), anaemia (HR 1.66, CI 1.21-2.27), deteriorated systolic function (HR 1.62, CI 1.19-2.20), and previous cardiovascular admissions (HR 2.33, CI 1.67-3.24). Residence in the Barbanza district was identified as an independent predictor of survival free from cardiovascular admission (HR 0.56, CI 0.37-0.86).
Conclusion:
Morbidity and mortality are currently high among Galician HF patients, and their best single predictor is previous hospitalization for cardiovascular reasons.
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