Related Experiment Video
Updated: Jul 3, 2026
A Silicosis Mouse Model Established by Repeated Inhalation of Crystalline Silica Dust
Published on: January 6, 2023
High prevalence and advanced silicosis in active granite workers: a dose-response analysis including FEV1
Gumersindo Rego1, Arturo Pichel, Aida Quero
1National Institute of Silicosis, Oviedo, Spain. Gumersino.rego@sespa.princast.es
Objective:
To evaluate silica exposure and respiratory disease in granite workers.
Methods:
A cross-sectional study of 440 active granite workers.
Results:
Seventy-seven (17.5%) have silicosis, complicated in 15 of them; 18 have an obstructive ventilatory defect and 73 had exceeded 3.5 mg/m-year of cumulative silica exposure. Percent predicted FEV1 have a significant negative relation with mg/m(3)-year (P < 0.001) with a trend toward dose-response excluding silicotics and controlling for tobacco. The odds ratio (95% confidence interval) of having a percent predicted FEV1 below 50th percentile is 1.18 (0.66 to 2.11) for nonexposed smokers, 1.47 (0.76 to 2.84) for exposed nonsmokers, and 2.07 (1.12 to 3.85) for exposed smokers, in comparison with the control group.
Conclusions:
This study suggests that silica induces functional alteration regardless of silicosis and, in all likelihood, synergistically with tobacco. Exposure levels must be controlled better in these workers and those with silicosis must be relocated to risk-free jobs or retired.
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