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Updated: Jul 3, 2026

Neonatal Murine Cochlear Explant Technique as an In Vitro Screening Tool in Hearing Research
Published on: June 8, 2017
Newborn hearing screening in infants with cleft palates
Judy L Chen1, Anna H Messner, Ginny Curtin
1Department of Otolaryngology and Communication Enhancement, Children's Hospital, Boston, Massachusetts, USA.
Newborns with cleft palate have a higher risk of hearing loss. Persistent hearing loss after tympanostomy tubes may be linked to cleft palate alone, female sex, or associated syndromes.
Area of Science:
- Audiology
- Pediatric Otolaryngology
- Craniofacial Anomalies
Background:
- Conductive hearing loss from serous effusion is common in infants with cleft palate.
- Early detection of hearing impairment is crucial for speech and language development in this population.
Purpose of the Study:
- To investigate the outcomes of newborn hearing screening in infants diagnosed with cleft palate.
- To identify factors associated with persistent hearing loss in this cohort.
Main Methods:
- Retrospective cohort review of 114 newborns with cleft palate (1999-2005).
- Analysis of hearing screening results, tympanostomy tube placement outcomes, and audiograms.
- Collection of data on sex, gestational period, screening type, post-tube hearing loss, and associated syndromes.
Main Results:
- 72% of newborns with cleft palate passed their initial hearing screen.
- Among those who failed and received tympanostomy tubes, 43% had persistent hearing loss.
- Cleft palate alone, female sex, and associated syndromes predicted persistent hearing loss.
Conclusions:
- Newborns with cleft palate demonstrate an elevated risk of failing newborn hearing screening.
- Diagnosing hearing loss unrelated to middle ear effusions is challenging in cleft palate patients due to high rates of otitis media.
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