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Updated: Jul 3, 2026

Measuring the Carotid to Femoral Pulse Wave Velocity (Cf-PWV) to Evaluate Arterial Stiffness
05:51

Measuring the Carotid to Femoral Pulse Wave Velocity (Cf-PWV) to Evaluate Arterial Stiffness

Published on: May 3, 2018

Relationship between arterial stiffness and myocardial damage in patients with newly diagnosed essential hypertension

Omer Gedikli1, Serkan Ozturk, Hulya Yilmaz

  • 1Faculty of Medicine, Department of Cardiology, Karadeniz Technical University, Trabzon, Turkey. omergedikli@yahoo.com

American Journal of Hypertension
|July 12, 2008
PubMed

Insights

Arterial stiffness is elevated in new hypertension cases. Increased arterial stiffness and body mass index are linked to higher heart-type fatty acid-binding protein (H-FABP) levels, a marker of heart damage.

Area of Science:

  • Cardiology
  • Hypertension Research
  • Biomarker Discovery

Background:

  • Arterial stiffness is a known complication of hypertension (HT), impacting cardiac function.
  • Serum heart-type fatty acid-binding protein (H-FABP) is a sensitive indicator of myocardial damage.
  • The association between arterial stiffness and H-FABP in newly diagnosed HT patients was previously unexamined.

Purpose of the Study:

  • To investigate the relationship between serum H-FABP levels and arterial stiffness in individuals with newly diagnosed hypertension.
  • To determine if arterial stiffness is a determinant of H-FABP levels in this population.

Main Methods:

  • A study involving 46 never-treated hypertensive patients and 40 normotensive controls.
  • Measurement of serum H-FABP levels using standard assays.
  • Assessment of arterial stiffness and wave reflections via applanation tonometry, including carotid-femoral pulse wave velocity (PWV) and heart rate-corrected augmentation index (AIx@75).

Main Results:

  • Hypertensive patients exhibited significantly higher carotid-femoral PWV and AIx@75 compared to controls.
  • Serum H-FABP levels were significantly elevated in the hypertensive group.
  • Multiple linear regression identified body mass index and carotid-femoral PWV as significant determinants of H-FABP levels.

Conclusions:

  • Arterial stiffness is significantly associated with elevated serum H-FABP levels in patients with newly diagnosed hypertension.
  • These findings suggest a link between vascular changes and myocardial strain in early hypertension.
Abstract

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