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Severe hypothyroidism after contrast enema in premature infants

Fanny Lombard1, Fabienne Dalla-Vale, Corinne Veyrac

  • 1CHU de Montpellier, Service de Néonatologie (Pédiatrie 2), Hôpital A. de Villeneuve, Montpellier, 34000, France.

European Journal of Pediatrics
|July 12, 2008
PubMed

Insights

Premature infants can develop severe hypothyroidism after iodine exposure from contrast agents. Careful consideration of contrast enemas and thyroid monitoring are crucial for vulnerable newborns.

Area of Science:

  • Neonatology
  • Pediatric Endocrinology
  • Radiology

Background:

  • Premature infants are susceptible to iatrogenic hypothyroidism from iodine exposure.
  • Common sources include disinfectants and iodinated contrast agents used in medical imaging.

Observation:

  • A case of severe iatrogenic hypothyroidism with goiter and cholestasis is presented.
  • This occurred six weeks after a contrast enema using sodium ioxitalamate in a premature infant.

Findings:

  • The infant's prematurity, intrauterine growth retardation, and feeding intolerance may have contributed to the complication.
  • Iodinated contrast agents can induce significant thyroid dysfunction in vulnerable neonates.

Implications:

  • Contrast enemas in neonates require careful consideration of risks and benefits.
  • Thyroid function monitoring is recommended for premature infants, particularly after exposure to iodinated contrast agents.

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