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Updated: Jul 3, 2026
Establishment of Epstein-Barr Virus Growth-transformed Lymphoblastoid Cell Lines
Published on: November 8, 2011
Plasma Epstein-Barr viral load predicting response after chemotherapy for post-transplant lymphoproliferative disease
Alex Sandro C Machado1, Alexandre Gustavo Apa, Lidia Maria Magalhães de Rezende
1Serviço de Hematologia, Hospital do Câncer I, Instituto Nacional do Câncer, Praça Cruz Vermelha, 20 230-130, Rio de Janeiro, Brazil.
Abstract:
Transplant patients are particularly at risk of developing B post-transplant lymphoproliferative disease (PTLD) related to intensive immunosuppressive treatment to prevent graft rejection. In EBV-positive PTLDs, EBV-DNA can be found in the patients' peripheral blood. Several methods have been described to assess peripheral blood EBV viral load. We report a case of a 13-year-old child who developed EBV-positive PTLD after renal transplantation. We assessed EBV plasma viral load by quantitative PCR and we found that the clearance of EBV-DNA correlated well with response to treatment.
