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Influence of alcohol on the release of tramadol from 24-h controlled-release formulations during in vitro dissolution
M J Traynor1, M B Brown, A Pannala
1School of Pharmacy, University of Hertfordshire, Hatfield, Hertfordshire, UK. m.j.traynor@herts.ac.uk
Abstract:
Recent warnings by regulatory bodies and a product recall by the FDA have generated much interest in the area of dose dumping from controlled-release opioid analgesic formulations when coingested with alcohol. It was the aim of this study to address this issue and in doing so, gain understanding on how alcohol-induced effects may be avoided. In this study, tramadol release from Ultram ER tablets and T-long capsules was significantly increased in the presence of ethanol. Conversely, a decrease in the rate of tramadol release was seen from Tridural extended-release tablets in the presence of alcohol.
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