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Updated: Jul 3, 2026

Structure and Coordination Determination of Peptide-metal Complexes Using 1D and 2D 1H NMR
Published on: December 16, 2013
A new Schiff base copper (II) complex derived from estrone and d-glucosamine: Synthesis, characterization and its
Xin-Bin Yang1, Li Wang, Ji Zhang
1Key Laboratory of Green Chemistry and Technology (Ministry of Education), Department of Chemistry, Sichuan University, Chengdu, P R China.
Abstract:
A novel copper (II) complex of Schiff base prepared through condensation between 2-formyl-17-deoxyestrone and d-glucosamine was synthesized and characterized. Fluorescence spectroscopy was conducted to assess their binding ability with CT-DNA. The results showed that the copper (II) complex could bind to DNA with a weak intercalative mode. The interaction between the copper (II) complex and DNA was also investigated by gel electrophoresis. Interestingly, we found that the complex could cleave plasmid DNA (pUC19) to nicked and linear forms through an oxidative mechanism without the use of exogenous agents.
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