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Intestinal Obstruction I: Introduction

Intestinal Obstruction I: Introduction

Intestinal obstruction is a partial or complete blockage of the small or large intestine that disrupts the normal flow of intestinal contents through the lumen. This interruption impairs digestion, absorption, and fluid balance, and may lead to serious complications if not treated promptly.Mechanical ObstructionMechanical obstruction occurs when a physical blockage prevents intestinal contents from passing, arising from within the lumen or the bowel wall, or from external compression.Adhesions,...

Intestinal Obstruction II: Pathophysiology

Intestinal Obstruction II: Pathophysiology

Intestinal obstruction triggers a series of physiological responses, starting with gas and fluid accumulation in the bowel segment proximal to the obstruction, leading to distension. This distended intestine compresses the diaphragm, hindering lung expansion and potentially leading to reduced respiratory effort, atelectasis, and pneumonia.To overcome the blockage, the gut intensifies contractions, causing colicky abdominal pain, nausea, and vomiting, which reduces fluid and food intake and...

Inflammatory Bowel Disease V: Surgical Management

Inflammatory Bowel Disease V: Surgical Management

Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:

Chronic Bowel Disorders: Introduction

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...

Pyloric Obstruction

Pyloric Obstruction

Pyloric obstruction, also referred to as gastric outlet obstruction, is a condition characterized by narrowing or blockage at the pylorus—the muscular valve regulating the flow of stomach contents into the duodenum. When this passage becomes impaired, the stomach cannot effectively empty its contents into the small intestine. This disruption leads to a range of gastrointestinal symptoms, including early satiety, bloating, epigastric pain, postprandial nausea, persistent vomiting, and...

Esophageal Strictures-II: Clinical Features and Management

Esophageal Strictures-II: Clinical Features and Management

Patients with esophageal strictures often experience a range of symptoms. Initially, they may have difficulty swallowing solid foods, which can progress to include liquids. Additional symptoms may involve chest pain or discomfort, regurgitating food and fluids, heartburn, unintentional weight loss, coughing or choking during meals, and hoarseness.
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...

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Related Experiment Video

Updated: Jul 3, 2026

A Mouse Model of Intestinal Partial Obstruction

A Mouse Model of Intestinal Partial Obstruction

Published on: March 5, 2018

[Chronic intestinal pseudo-obstruction--review and update 2008].

H Seidl¹, C Pehl, W Schepp

¹Abteilung für Gastroenterologie, Hepatologie und Gastroenterologische Onkologie, Klinikum München-Bogenhausen, München. H.Seidl@lrz.tum.de

Zeitschrift Fur Gastroenterologie

|July 12, 2008

Summary

Chronic intestinal pseudo-obstruction involves severe motility issues mimicking blockages. Management includes total parenteral nutrition (TPN), surgery, or transplantation for life-threatening cases.

More Related Videos

Functional Assessment of Intestinal Motility and Gut Wall Inflammation in Rodents: Analyses in a Standardized Model of Intestinal Manipulation

Functional Assessment of Intestinal Motility and Gut Wall Inflammation in Rodents: Analyses in a Standardized Model of Intestinal Manipulation

Published on: September 11, 2012

Related Experiment Videos

Last Updated: Jul 3, 2026

A Mouse Model of Intestinal Partial Obstruction

A Mouse Model of Intestinal Partial Obstruction

Published on: March 5, 2018

Functional Assessment of Intestinal Motility and Gut Wall Inflammation in Rodents: Analyses in a Standardized Model of Intestinal Manipulation

Functional Assessment of Intestinal Motility and Gut Wall Inflammation in Rodents: Analyses in a Standardized Model of Intestinal Manipulation

Published on: September 11, 2012

Area of Science:

Gastroenterology
Neurology
Pathology

Context:

Chronic intestinal pseudo-obstruction (CIPO) is a motility disorder clinically mimicking mechanical bowel obstruction.
It stems from neuropathies or myopathies affecting the gastrointestinal nervous system.
A significant portion of patients require long-term total parenteral nutrition (TPN).

Purpose:

To outline the diagnostic and therapeutic approaches for CIPO.
To classify the underlying causes of CIPO.
To discuss evolving management strategies for this complex condition.

Summary:

CIPO presents as severe alterations in gastrointestinal motility.
Pathologies include intrinsic/extrinsic nervous system neuropathies and myopathies.
Treatment may involve TPN, emergency surgery, or small bowel transplantation.

Impact:

Improved understanding of CIPO pathogenesis and therapeutic options.
Facilitates a differentiated diagnostic and treatment strategy.
Aids in managing patients with severe gastrointestinal motility disorders.