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Related Experiment Video

Updated: Jul 3, 2026

Separation of Bioactive Small Molecules, Peptides from Natural Sources and Proteins from Microbes by Preparative Isoelectric Focusing (IEF) Method

Separation of Bioactive Small Molecules, Peptides from Natural Sources and Proteins from Microbes by Preparative Isoelectric Focusing (IEF) Method

Published on: June 14, 2020

Protein separation by differential drainage from foam.

S B Mohan¹, A Lyddiatt

¹School of Chemical Engineering, University of Birmingham, Birmingham B15 2TT, United Kingdom.

Biotechnology and Bioengineering

|November 20, 1994

Summary

Foam fractionation can further enrich low-concentration beer components beyond initial foaming. Differential drainage from collapsed foam offers a novel method for separating proteins and other valuable compounds.

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Area of Science:

Food Science
Separation Science
Biochemistry

Background:

Beer is a complex mixture of yeast, malt, and hop components.
Foam fractionation is a technique used to separate components from liquids.
The primary foaming stage in beer concentrates most components.

Purpose of the Study:

To investigate the potential of foam fractionation beyond the initial foaming stage.
To demonstrate further enrichment of beer components using differential foam drainage.
To explore novel fractionation methods for low-concentration beer constituents.

Main Methods:

Utilized commercially available beer as a model system.
Collected and analyzed collapsed foam over a 30-minute period.
Observed differential drainage of components from the foam structure.

Main Results:

Most beer components concentrated in the initial foam.
Differential drainage led to further enrichment of specific components.
Components present in low initial concentrations showed significant enrichment.

Conclusions:

Foam fractionation has potential beyond the primary foaming stage.
Preferential foam drainage offers a novel fractionation method.
This technique can be used to further fractionate proteins and other low-concentration components in beer.