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Related Concept Videos

Hyperthyroidism II: Pathophysiology01:27

Hyperthyroidism II: Pathophysiology

Hyperthyroidism is a hypermetabolic state caused by elevated levels of thyroid hormones, triiodothyronine (T3) and thyroxine (T4). It results from dysregulation at the thyroid, pituitary, or immune system level and affects multiple organ systems.PathophysiologyThe most common cause of hyperthyroidism is Graves’ disease, an autoimmune disorder in which antibodies, specifically thyroid-stimulating antibodies (TSAb), a subtype of TSH receptor antibodies (TRAb), bind to and activate TSH receptors...
Larynx01:21

Larynx

The human larynx, often referred to as the voice box, is an intricate organ located in the neck. It serves as a pathway for air to enter the lungs during respiration and is an essential component of voice production.
Anatomy of the Larynx
The larynx consists of various components, including cartilage, muscles, and vocal cords. Its structure includes three large unpaired cartilages—the thyroid, cricoid, and epiglottis—and three smaller paired cartilages—the arytenoids, corniculates, and...
The Thyroid Gland01:23

The Thyroid Gland

The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
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Goiter refers to an abnormal enlargement of the thyroid gland that may appear as a diffuse goiter (uniform enlargement) or nodular (single or multiple nodules). Functionally, it is classified as nontoxic (normal/low hormone levels) or toxic (excess hormone production).PathophysiologyDiffuse thyroid enlargement typically results from prolonged stimulation by thyroid-stimulating hormone (TSH) or TSH-like agents, commonly seen in hypothyroidism or iodine deficiency. In contrast, in hyperthyroid...
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Hypothyroidism II: Pathophysiology

Hypothyroidism is a disorder characterized by insufficient production of thyroid hormones, which regulate metabolism, energy balance, and multiple organ systems.TypesHypothyroidism is classified based on the level of dysfunction. Primary hypothyroidism results from intrinsic thyroid gland dysfunction, causing reduced hormone production despite normal or increased stimulation. Secondary hypothyroidism arises from inadequate thyroid-stimulating hormone (TSH) secretion by the pituitary. Tertiary...
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Related Experiment Video

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Identification and Protection of the Recurrent Laryngeal Nerve during Transoral Robotic Thyroidectomy
05:25

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Published on: October 24, 2025

Risk factors for transient vocal cord palsy after thyroidectomy.

J J Sancho1, M Pascual-Damieta, J A Pereira

  • 1Endocrine Surgery Unit, Department of Surgery, Hospital del Mar, Barcelona, Spain. jjsancho@gmail.com

The British Journal of Surgery
|July 12, 2008
PubMed
Summary
This summary is machine-generated.

Surgical injury to the inferior laryngeal nerve (ILN) during thyroidectomy can cause vocal cord dysfunction (VCD). Branched ILNs are more susceptible to injury and double the risk of VCD.

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Area of Science:

  • Otolaryngology
  • Thyroid Surgery
  • Nerve Anatomy

Background:

  • Transient recurrent laryngeal nerve palsy occurs in 5-10% of patients post-thyroidectomy.
  • Understanding the impact of inferior laryngeal nerve (ILN) injury on vocal cord dysfunction (VCD) is crucial.

Purpose of the Study:

  • To assess the impact of surgical injury and extralaryngeal branching of the ILN on VCD.
  • To determine the relationship between ILN anatomy and post-thyroidectomy vocal cord function.

Main Methods:

  • Prospective study of 188 patients undergoing total or lobar thyroidectomy (302 ILNs).
  • Recorded ILN anatomy, extralaryngeal branching, and degree of injury using the Laryngeal Nerve Injury Score (LNIS).
  • Performed fibreoptic laryngoscopy to assess VCD post-surgery.

Main Results:

  • 37.4% of ILNs exhibited extralaryngeal branching.
  • VCD developed in 10.9% of patients (4.3% paresis, 6.6% paralysis), with most recovering fully.
  • VCD was significantly more frequent in patients with branched ILNs (15.8% vs. 8.1%, P=0.022).
  • Branched nerves had higher injury scores (LNIS 0.94 vs. 0.51, P<0.001) and were twice as likely to be associated with VCD (OR 2.2).

Conclusions:

  • Extralaryngeal branching of the ILN is common and associated with increased surgical injury.
  • Branched ILNs are significantly more likely to result in vocal cord dysfunction after thyroidectomy.