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Updated: Jul 3, 2026
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Whole Genome Sequencing of Candida glabrata for Detection of Markers of Antifungal Drug Resistance
Published on: December 28, 2017
[Antifungal resistance: an emerging problem in Mexico]
Patricia Manzano-Gayosso1, Luis J Méndez-Tovar, Francisca Hernández-Hernández
1Laboratorio de Micología Médica, Departamento de Microbiología y Parasitología, Facultad de Medicina, UNAM, México D.F., México. angelesmg@liceaga.facmed.unam.mx
Gaceta Medica De Mexico
|July 16, 2008
Summary
Antifungal drug resistance is a growing concern, with Mexican studies showing significant resistance in dermatophytes (20%) and yeasts (27.5%), potentially leading to treatment failures.
Area of Science:
- Medical Mycology
- Antimicrobial Resistance
- Infectious Diseases
Background:
- Global increase in mycosis and therapeutic failure.
- Limited data on antifungal resistance in Mexico.
- Need to investigate drug resistance patterns in local patient populations.
Purpose of the Study:
- To determine the prevalence of antifungal resistance in dermatophytes and Candida species in Mexico.
- To identify specific antifungal drugs to which these fungi exhibit resistance.
- To correlate observed resistance patterns with clinical therapeutic failures.
Main Methods:
- Inclusion of 76 isolates from patients: 36 dermatophytes and 40 Candida spp.
- Antifungal susceptibility testing using E-test for dermatophytes.
- Broth microdilution method for Candida spp.
- Testing against itraconazole, ketoconazole, fluconazole, voriconazole, and amphotericin B.
Main Results:
- 19.4% of dermatophyte isolates showed resistance to one or more antifungals (Trichophyton spp.).
- 27.5% of Candida isolates exhibited resistance, primarily to azoles (ketoconazole, itraconazole, fluconazole, voriconazole).
- No Candida isolates demonstrated resistance to amphotericin B.
Conclusions:
- Antifungal drug resistance is a significant factor contributing to treatment failure in mycosis.
- The study identified notable resistance rates in Mexican isolates of dermatophytes and yeasts.
- Findings highlight the importance of monitoring antifungal resistance for effective clinical management.
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