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Identifying PD-1/PD-L1 Inhibitors with Surface Plasmon Resonance Technology
Published on: May 2, 2025
[A new therapeutic strategy to control HIV? The PD1 molecule and its role in inhibiting cellular immune responses]
María Candela Iglesias-Chiesa1, Brenda Crabtree-Ramírez, Gustavo Reyes-Terán
1Centro de Investigación en Enfermedades Infecciosas, Instituto Nacional de Enfermedades Respiratorias, SSA., México D.F., México. candela.iglesias@cieni.org.mx
Abstract:
CD8+ T cells are crucial in protecting against viral infections by secreting antiviral factors and lysing infected cells. The loss of these functions is a hallmark of various chronic viral infections. In HIV chronic infection, CD8+ T cells develop this exhausted phenotype and their protection capacities diminish. Recently, it has been shown that a co-inhibitory molecule called PD-1 plays an important role on this exhausted phenotype. These findings open up the possibility of research targeted to develop therapeutic interventions that may restore CD8+ T cell function in chronic HIV infection.
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