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Updated: Jul 3, 2026
07:35
Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring
Published on: June 23, 2015
Polycystic kidney disease: will it become treatable?
1Nephrology, Department of Medicine, Universitätsklinikum C. G. Carus, Dresden, Germany. Peter.Gross@uniklinikum-dresden.de
Polskie Archiwum Medycyny Wewnetrznej
|July 16, 2008
Summary
Polycystic kidney disease (PKD) is an inherited disorder causing kidney dysfunction. Novel treatments targeting the disease
Area of Science:
- Nephrology and Genetics
Background:
- Polycystic kidney disease (PKD) is an inherited multisystem disorder.
- It leads to progressive kidney function loss, flank pain, infections, hypertension, and vascular issues.
Purpose of the Study:
- To explore novel treatment protocols for PKD.
- To move beyond symptomatic treatment towards addressing the disease's origin.
Main Methods:
- Utilizing cell culture of cyst wall epithelia.
- Leveraging the discovery of polycystins 1 and 2.
Main Results:
- Identification of new therapeutic targets and strategies.
- Development of novel treatment protocols.
Conclusions:
- New approaches offer the potential to treat the root cause of PKD.
- Current novel protocols include vasopressin antagonists, rapamycin, and somatostatin.
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